Highly Functionalized Fine Organic Compounds

Our ability to prepare functionalized organometallic reagents provides an entry to thousands of original highly functionalized fine organic molecules. Rieke highly reactive zinc readily undergoes oxidative addition to alkyl, aryl, vinyl and heterocyclic halides under mild conditions to generate the corresponding organozinc reagent. Significantly, this reaction will tolerate any functionality in the halide and this route provides hundreds of functionalized organozinc reagents. Cross coupling these reagents with a wide range of electrophiles and catalysts yields an extensive list of functionalized fine organic compounds. These exciting molecules are proving to be extremely valuable building blocks for the pharmaceutical and chemical industry.