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Creating Custom Molecules: A Team Effort

Materials science has made massive gains in the last 100 years. With increasingly complex problems to solve, our solutions need to be highly-optimized, cost-efficient and most importantly, sustainable. This is particularly true when your product involves the creation of a unique molecule or novel route of synthesis.

When a molecule is not already in market, resources are well-spent outsourcing its development. It’s best to lean on the expertise of an experienced contract research organization to focus on custom synthesis challenges while you work on shaping your vision for the future — and ensuring that your company is ready for future competition.

Developing Your Strategy

It all begins with developing a efficient route of synthesis (ROS). This will protect your company’s time and material use. It also ensures the largest product yield. The second most important factor is the ability to scale up your ROS: Can your design transition from the lab bench to the plant? The answer to that question is simple: Make a kilo of product.

Kilo labs help you test-run your product before you make the big (and expensive) leap to a large-scale manufacturing facility. This is a crucial step to predict success and well worth the time and money. A surprise at plant level is a lot harder to resolve than a surprise in the kilo lab.

So how do you choose the right contract research organization for your company?

Picking Your Team

In the United States, government spending for research and development is on the rise and shows no signs of slowing. In fact, R&D spending across multiple sectors is projected to reach $600 billion by 2021.

The U.S. federal government offers a tax credit for research and development performed in the country. However, some companies don’t take advantage of the R&D tax credit, fearing complications of an audit. An experienced lab can offer professional management of your documentation to help your business benefit from this program.

Another advantage of domestic R&D is that it benefits the U.S. economy. When U.S. companies outsource R&D to other countries, they cede opportunities for productivity, growth and competitiveness. They also threaten their intellectual property.

Outsourcing scientific work may appear to create advantages, but there is no guarantee that your intellectual property will be fully protected. The laws that govern intellectual property (such as trade secrets, patents, and industrial designs) vary by country. Outsourcing R&D can leave companies vulnerable to monitoring challenges, theft of trade secrets, the inability to enforce certain intellectual property rights and inconsistencies in quality that can threaten your reputation. These complications can also incur staggering legal costs.

Innovating Together

With over 20 years of active metal and inert atmosphere chemical experience, Rieke Metals has a proven track record of solving synthesis challenges while keeping intellectual property secure. Our ability to scale from grams to kilograms provides continuity from the bench to the factory. You can rely on our full-service team as a bridge between R&D and commercial production, with the ability to:

  • Design a custom ROS for molecules that are temperature, moisture and air-sensitive.
  • Enhance a current ROS to improve yield, quality and purity.
  • Scale up a current ROS to ensure that you maintain yield and quality at scale.
  • Develop unique molecules to suit your specific needs.
  • Create a specification profile for your unique molecule to ensure consistency and quality of each shipment.

Chemistry That Focuses on Quality

Rieke Metals’ team of highly-skilled organic chemists specialize in handling air and moisture-sensitive materials.

We are highly experienced in the following reactions:

  • Active metals (eg. zinc and magnesium)
  • Grignard chemistry
  • Organozinc chemistry
  • Organometallic chemistry
  • Transition metal coupling chemistry
  • Polymerization

Additionally, Rieke Metals is available to perform the following transition metal catalyzed cross-coupling technologies:

R-X + R’-M → R-R’

  • Negishi
  • Cuprates
  • Stille
  • Suzuki & Molander
  • Hiyama
  • Olefin
  • Heck
  • Amination Buchwald & Hartwig
  • CO Nuleophile
  • Carbonylation
  • Acetylide
  • Sonagashira
  • Kumada

If there’s one thing we can depend upon in an evolving materials science market, it’s that innovation yields more innovation. But more doesn’t always mean better. Quality matters, and producing quality materials is a team effort.